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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLDN4
All Species:
26.67
Human Site:
S198
Identified Species:
65.19
UniProt:
O14493
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14493
NP_001296.1
209
22077
S198
K
P
Y
S
A
K
Y
S
A
A
R
S
A
A
A
Chimpanzee
Pan troglodytes
XP_523276
220
23303
S201
S
H
Y
M
A
R
Y
S
T
S
A
P
A
I
S
Rhesus Macaque
Macaca mulatta
XP_001112477
209
22011
S198
K
P
Y
S
A
K
Y
S
A
A
R
S
A
A
A
Dog
Lupus familis
XP_546920
210
22073
S198
K
P
Y
S
A
K
Y
S
A
A
A
R
S
A
P
Cat
Felis silvestris
Mouse
Mus musculus
O35054
210
22320
S199
K
P
Y
S
A
K
Y
S
A
A
R
S
V
P
A
Rat
Rattus norvegicus
Q63400
219
23296
Y197
Y
A
P
T
K
I
L
Y
S
A
P
R
S
T
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510834
206
21755
S195
K
P
Y
S
A
K
Y
S
A
A
R
S
A
P
T
Chicken
Gallus gallus
NP_989533
214
23072
A197
R
Y
A
P
S
K
V
A
Y
S
A
P
R
S
A
Frog
Xenopus laevis
NP_001089583
209
22234
T198
K
P
Y
S
A
K
Y
T
A
A
R
S
G
A
T
Zebra Danio
Brachydanio rerio
Q9YH91
208
22187
S198
R
A
Y
S
V
K
Y
S
A
P
R
S
A
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
60
99
90.9
N.A.
83.3
64.3
N.A.
84.6
67.2
75.1
65.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
80
99.5
95.7
N.A.
94.2
80.3
N.A.
93.7
84.5
90.9
82.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
33.3
100
73.3
N.A.
86.6
6.6
N.A.
86.6
13.3
80
60
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
53.3
100
80
N.A.
86.6
26.6
N.A.
86.6
46.6
86.6
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
10
0
70
0
0
10
70
70
30
0
50
40
40
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
20
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% I
% Lys:
60
0
0
0
10
80
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
60
10
10
0
0
0
0
0
10
10
20
0
30
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
20
0
0
0
0
10
0
0
0
0
60
20
10
0
0
% R
% Ser:
10
0
0
70
10
0
0
70
10
20
0
60
20
10
10
% S
% Thr:
0
0
0
10
0
0
0
10
10
0
0
0
0
10
20
% T
% Val:
0
0
0
0
10
0
10
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
10
80
0
0
0
80
10
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _